The associated antigens, p, p k and lke, are not included in the p blood group system but are mentioned here for convenience. The lutheran 005 blood group system blood type antibody. Gil, the only antigen of the gill system, is an antigen of high prevalence located on the water and glycerol channel aquaporin3 aqp3. Presently, blood group antigens have been numbered by the international society of blood transfusion isbt working party on red cell immunogenetics and blood group terminology. How to read the new isbt 128 label isbt 128 ready facility if your transfusion service is using the new character donation number plus manual check character. Castilho, in brenners encyclopedia of genetics second edition, 20 biochemistry and genetics. Isbt human blood group systems isbt number name abbreviation 001 abo abo 002 mns mns 003 p p 004 rh rh 005 lutheran lu 006 kell kel 007 lewis le 008 duffy fy 009 kidd jk 010 diego di 011 cartwright yt 012 xg xg 0 scianna sc 014 dombrock do 015 colton co 016 landsteinerwiener lw 017 chidorodgers chrg 018 hh h.
Gill blood group system the gill blood group system was added to the list of systems already recognized by the isbt in 2002. Blood group systems smart 2008 isbt science series. Over 30 human blood group systems are now recognized 1. Rbcs, erythropoietic tissues, testes lower expression in brain, lymphoid organs, muscle heart and skeletal. Blood, tissues, cellular therapy, ocular, human milk, topical products of human. Each blood group system represents either a single gene or a cluster of closely linked homologous genes. Blood group system an overview sciencedirect topics. People with the rare jra negative blood type can develop antijra antibodies, which may cause transfusion reactions and hemolytic disease of the newborn on subsequent exposures. The following sections describe the terminology for each of the families of products supported by isbt 128. Update on blood group terminology and molecular polymorphisms. The sid blood group system is a human blood group defined by the presence or absence of the sda antigen also known as sid antigen on a persons red blood cells. Blood group systems page 1 start with listings with each line having hyperlink to full section in the rest of this document.
One antigen was made obsolete based on additional data. Blood group systems smart 2020 isbt science series wiley. A blood group system is one or more blood group antigens encoded either by a single gene or by a cluster of two or more closely linked, homologous genes. International society of blood transfusion working party. The new ab was named lutheran, a misinterpretation of the donors name. The isbt terminology designates a number and a symbol for every blood group system, eg, number 001 and symbol abo for the abo blood group system, and number 009 and symbol jk for the kidd blood group system 1,2. O cells show the strongest antigen expression, a 1 b cells the weakest. The fydarc duffy blood group, chemokine receptor gene is located in chromosome 1 and consists of two exons distributed over 1. Sep 14, 2011 a table for each blood group system in which the reference allele is shaded. Standard terminology 7 welcome to the isbt 128 website. The remaining 38 antigens are currently unassigned to a known system. The original publication of introduction to blood transfusion technology consisted of 150 pages and included the fundamentals of haematology, immunology, antigenantibody reactions, causes of false results, genetics, blood group and hla systems, blood donation and storage, blood components, safety in the laboratory, quality control and.
Isbt human blood group systems isbt number name abbreviation 001 abo abo 002 mns mns 003 p p 004 rh rh 005 lutheran lu 006 kell kel 007 lewis le 008 duffy fy 009 kidd jk 010 diego di 011 cartwright yt 012 xg xg 0 scianna sc 014 dombrock do 015 colton co 016 landsteinerwiener lw 017 chidorodgers chrg 018 hh h 019 kx xk 020 gerbich ge 021. Xg isbt no 012 blood group system antixga xg1 rare most some most ii some no no 89 females, 66 males dombrock isbt no 014 blood group system antidoa do1 ayes yes h positive dat but no clinical hdfn delayed and acute hemolytic 67 55 japanese. System name system symbol gene names chromosomal location cd numbers 001 abo abo abo 9q34. Antib antia 1 mns blood group system antim antin antis antis antiu antibodies to lowincidence antigens in the mns blood group system. Reid original report application of realtime pcr and melting curve analysis in rapid diego blood group. Table 61 major blood group systems 9 of 29 isbt no blood group system name major antigens chromosome location no. It deals with the relationship between information held in the gs1 carton codes and the isbt 128 blood. The junior blood group system was discovered in 1970 by researchers stroup and macillroy, who reported on five patients whose blood was incompatible with all samples tested except each others.
Lutheran ags have been recognized since 1945 when the first example of an antilu a was discovered in the serum of a patient with lupus ertythematosus diffusus, following the transfusion unit of blood carrying the corresponding lowincidence antigen. Several nomenclatures have been used to describe antigens, proteins, and genes in the rh system. It was first discovered in 1939 but confirmed in 1940 in a series of experiments performed by landsteiner and weiner in which they evaluated the immunologic response of rabbits injected with rbcs. International society of blood transfusion working party on. Table 1 the blood group systems, the genes that encode them, their chromosomal locations, and. Isbt working party on terminology for red cell surface antigens, authorg. For example, d is rh1, c is rh2, e is rh3, c is rh4, and e is rh5, and. Background jra isbt 901005 is a highprevalence antigen unassigned to a blood group system. Table 2 examples of antigen, phenotype, gene, and genotype designations in international society of blood transfusion isbt and traditional terminologies.
This name comprises the isbt gene symbol and a serological representation of the allele i. System name system symbol gene names number of antigens chromosomal location cd numbers. Sep 02, 2016 antigens that are authenticated by the international society of blood transfusion isbt working party for red cell immunogenetics and blood group terminology fall into one of four classifications. St001 isbt 128 standard technical specification pdf 2 mb the purpose of this document is to provide standards and guidance for the coding and labeling of medical products of human origin mpho. The lan blood group system short for langereis is a human blood group defined by the presence or absence of the lan antigen on a persons red blood cells. Some systems contain only one determinant, while others, such as rh and mns, contain many. Meny original report rhcecear encodes a partial c rh4 antigen c. Old component code system unable to systematically name modified products with multiple attributes, e. System name system symbol gene names number of antigens chromosomal location cd numbers 001 abo abo abo 4 9q34. Table 62 other blood group systems isbt no blood group system name main antigens chromosome location no. A table for each blood group system in which the reference allele is shaded. Red cell immunogenetics and blood group terminology. The presence or absence of each antigen on the red blood cell rbc is noted by the designation rh.
The rh blood group system, isbt number 004symbol rhcd number cd240dcd240ce is complex and contains many antigens that are highly immunogenic. They named the causative antigen jr after rose jacobs, one of the five patients the common name junior is in fact a misnomer. The term human blood group systems is defined by international society of blood transfusion as systems in the human species where cellsurface antigensin particular, those on blood cellsare controlled at a single gene locus or by two or more very closely linked homologous genes with little or no observable recombination between them, and include the common abo and rh rhesus antigen. Red cell immunogenetics and blood group terminology isbt.
Pdf abo and rh blood group systems are the most important blood grouping systems from clinical. Nov 12, 2018 fifteen new blood group antigens were added to eight blood group systems. Human blood group systems an overview sciencedirect topics. System antigen number 001 002 003 004 005 006 007 008 009 010. To assign a number, the blood group antigen is defined serologically by antibodies made by humans. If used provides rh, kell phenotype as part of blood group structure e reserved for future use. Apart from abo and rhesus system, many other types of antigens. The junior blood group system or jr is a human blood group defined by the presence or absence of the jra antigen, a highfrequency antigen that is found on the red blood cells of most individuals.
The blood group antigen factsbook winner of a 20 highly commended bma medical book award for internal medicine has been an essential resource in the hematology, transfusion and immunogenetics fields since its first publication in the late 1990s. For example, d is rh1, c is rh2, e is rh3, c is rh4, and e is rh5, and so on. Blood group systems not described in the other chapters are discussed here, as well as antigens that have not yet been assigned to a blood group system. International society of blood transfusion isbt first used in blood bank in estonia in 1997. There are now 41 formally registered blood group systems. The rh blood group system consists of two genes rhd and rhce on chromosome 1 1p36.
Journal of blood group serology and molecular genetics. Consequently, the current total of blood group antigens recognized by the isbt is 360, of which 322 are clustered within 36 blood groups systems. In the following, the label paradigm of codabar in macao blood transfusion center ctsmacau is bank environment, it is essential to label blood and blood examined through the comparison with isbt 128, an products for electric data processing systems. Blood group duffy system an overview sciencedirect topics. Mpho, including blood, organs, bone marrow, cord blood, corneas, tissues, reproductive cells and human milk, to ensure recipient safety and called for the global adoption of isbt 128 as the coding system for. The rh blood group system connie westhoff t he rh blood group system is one of the most polymorphic and antigenic blood group systems. This document is intended to provide guidanceto blood bag manufacturers, their customers, and software developers on the bar coding of blood bags and their shipping containers. People lacking this antigen have been found in all populations studied but most commonly in asians. The rhd gene arose as a duplication of the rhce gene in the common ancestors of humans, chimpanzees, and gorillas 37. In the past decade, intense investigation has yielded considerable knowledge of the molecular. P 1 is the blood group antigen in the p system isbt 003 and the terminology p 2 indicates the lack of p 1 antigen.
Antigen number 001 002 003 004 005 006 007 008 009 010 011. The rh blood group system is one of the most polymorphic and immunogenic systems known in humans. Individuals with the rare lannegative blood type, which is a recessive trait, can produce an antilan antibody when exposed to lanpositive blood. The third edition of the blood group antigen factsbook has been completely revised, updated and expanded to cover all 33 blood group systems. The duffy blood group system consists of fy a, fy b, fy 3 and fy 6 antigens carried on the erythrocyte chemokine receptor known as the duffy antigen receptor for. Apart from abo and rhesus system, many other types of antigens have been noticed on the red cell membranes. The kell blood group system isbt 006 1st antibody antik, identified in 1946 in a report of hdfn 36 antigens kell is expressed on. The international society of blood transfusion isbt working party for red cell immunogenetics and blood group terminology meets in association with the isbt congress and has met three times since the last report. Consequently, the current total of blood group antigens recognized by the isbt is. International society of blood transfusion working party on red. Scianna blood group system isbt 0 antisc1 antisc2 dombrock blood group system antidoa antidob antigya antihy antijoa colton blood group system anticoa. International society of blood transfusion isbt terminology assigns each antigen a number. Mpho, including blood, organs, bone marrow, cord blood, corneas, tissues, reproductive cells and human milk, to ensure recipient safety and called for the global adoption of isbt 128 as the coding system. The mns blood group system consists of the antigens m, n, s, s and u, which are determinants on glycophorins a and b and antibodies to these antigens can be clinically significant.
This great contribution to medicine was made by landsteiner in 1900 when he observed that the serum of healthy humans not only has an agglutinating effect on animal blood corpuscles, but also on human blood. There are 30 blood group systems recognized by the international society for blood transfusion isbt table 1. The international society of blood transfusion isbt classifies red blood cell rbc antigens and also denotes them as. Rh blood group system an overview sciencedirect topics. Name of blood group system main antigens chromosome location no. The p antigen has been allocated to the globoside blood group system 028. Proceedings from the international society of blood. Ina in1, which is present in approximately 10 percent of some arab populations and in 3 percent of bombay.
After landsteiner discovered the abo system in the early 1900s, he began to search for additional antigens that would differentiate people. Langcamon, rmt isbt blood group system 001 abo 002 mnss 003 p1pk 004 rh 005 lutheran 006 kell 007 lewis 008 duffy 009 kidd 010 diego 011 cartwright 012 xg 0 scianna 014 dombrock 015 colton 016 landsteinerwiener 017 chidorodgers 018 h 019 kx 020 gerbich 021 cromer 022 knops 023 indian 024 ok 025 raph 026 john milton hagen. About 96% of people are positive for the sda antigen. The p and lke antigens are controlled by genes at a different locus to that for p 1 antigen. In 1927, he identified a second blood group system. Most blood group antigens are glycoproteins and their specificity is mostly determined either by the oligosaccharide e. Introduction to the isbt 128 labelling standard for blood. The abo system is the most important blood group system in transfusion therapy and was the first blood group system to be discovered. International society of blood transfusion has recently recognized 33 blood group systems.
Langcamon, rmt isbt blood group system 001 abo 002 mnss 003 p1pk 004 rh 005 lutheran 006 kell 007 lewis 008 duffy 009 kidd 010 diego 011 cartwright 012 xg 0 scianna 014 dombrock 015 colton 016 landsteinerwiener 017 chidorodgers 018 h 019 kx 020 gerbich 021 cromer 022 knops 023 indian 024 ok 025 raph 026 john milton hagen 027 i 029 gill 030 rhag 1. Note that h antigen is in a separate system, h isbt h 018, and is not part of the abo system isbt abo 001 table 2 provides information on blood group systems other than the ten major systems. Extended isbt 128 label canadian blood services plans to use an extended isbt 128 label for a transition period to allow hospital systems time to become isbt 128 compliant duration of transition period has not yet been determined extended portion of label has critical information donation number, product code, blood group. If used provides rh, kell phenotype as part of blood group structure e reserved for.
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